Folklore Clinical Variant Interpretation MCP

Connect it to your AI

Claude Code

claude mcp add --transport http folklore https://api.helena.bio/folklore/v1/mcp

Claude, ChatGPT, Cursor and other apps

Add it as a custom connector with this URL (Streamable HTTP):

https://api.helena.bio/folklore/v1/mcp

Cursor, VS Code and other apps (mcp.json)

{
  "mcpServers": {
    "folklore": {
      "url": "https://api.helena.bio/folklore/v1/mcp"
    }
  }
}

Tools it offers

11 tools, as the server itself reported during our check on Oct 31, 2026.

• search_variant_evidenceInterpret this variant, explain what this HGVS means, or review this VUS. Use for human genomic variant analysis within bioinformatics workflows, including review of an already identified WGS/WES variant. Use when a user
• search_variant_literatureResolve one public GRCh38 germline variant and retrieve relevant publications from Folklore's PubMed-derived genetics corpus. Exact variant mentions rank ahead of broader gene associations. Use when a user asks what has
• get_publication_detailsRetrieve the complete public bibliographic record for one PMID from Folklore's PubMed-derived genetics corpus. Returns the full abstract, authors, journal metadata, publication and MeSH terms, gene and variant mentions,
• search_literature_corpusSemantically search the public scientific Literature Corpus by a natural-language question. A question may include one or more PMID, DOI or PMCID references; those publications become exact anchors for finding related ex
• support_helenaLearn how an agent can support or spread Helena's free public scientific infrastructure through the separate Helena Good MCP. This is an explicit opt-in information action. It does not initiate payment, create a relay, o
• get_gene_disease_associationsFind diseases associated with one human gene for bioinformatics and clinical genomics research. Accepts an exact gene symbol or HGNC identifier. Returns ClinGen gene-disease validity assertions, relation-specific inherit
• search_disease_genesFind human genes associated with a disease for genomic analysis and rare-disease research. Accepts an exact MONDO identifier or a disease-name search. Returns matching ClinGen gene-disease validity assertions with inheri
• resolve_geneFind the authoritative public human gene identity for a symbol, previous symbol, alias, HGNC, Ensembl or NCBI Gene identifier. Returns exact, alias, ambiguous, not_found or withdrawn with all candidates and identity_snap
• get_gene_profileRead one source-qualified gene profile after resolve_gene and explicit candidate selection when needed. Returns the same immutable snapshot as the public Folklore gene page: overview, disease validity, dosage, mechanisms
• get_gene_sectionRead or continue one section of the current public gene profile using its exact gene_id, snapshot_id and opaque section cursor. Preserves source records, assembly/release, coverage, total versus observed_total, count uni
• search_gene_literatureRetrieve the public gene page live literature capture after authoritative gene resolution. Uses the canonical gene context and existing Literature Mining ranking. Returns publications, source links, match labels, capture

Questions